Figure 4.

Effects on tumour volume of treatment (s.c.) with Spn/SA2E with 10 min interval between injections (n= 9), Spn/SA2E with 60 min interval between injections (n= 9) and sham-treated BALB/c mice (n= 9). Each group was treated six times with the indicated drugs, beginning on day 6 and continuing twice per week, and the experiment ended on day 27. Only mice with developing tumours were used for the experiment. Tumour volume (shown as means ± SD) was calculated, assuming a spheroid. * indicates significantly (P < 0.05) reduced tumour volume in comparison with the sham-treated mice. Spn, Saponinum album from Gypsophila paniculata L.