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Effects of PDE4 inhibitors on cAMP levels in rat carotid bodies (CBs). Concentration–response curves of (A) rolipram, (B) Ro 20-1724 and (C) isobutylmethylxanthine (IBMX) for effects on cAMP levels induced during normoxia (20%O2) [0% effect − 0.75 ± 0.08 pmol cAMP/mg (n= 15) ] and hypoxia (5%O2) (0% effect − 0.63 ± 0.05 pmol cAMP/mg (n= 15). *P < 0.05 and ***P < 0.001 two-way analysis of variance with Bonferroni's post hoc test. Data values represent means ± SEM.
