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Effects of PDE4 inhibitors on cAMP levels in rat carotid arteries (CAs) incubated in normoxia [20%O2; 0% of effect corresponds to 0.19 ± 0.02 pmol·mg−1 (n= 12) ] and hypoxia [5%O2; 0% of effect corresponds to 0.11 ± 0.01 pmol·mg−1 (n= 11) ]. Concentration–response curve of (A) rolipram, (B) Ro 20-1724 and (C) isobutylmethylxanthine (IBMX) for effects on cAMP levels. **P < 0.01 and ***P < 0.001 two-way analysis of variance with Bonferroni's post hoc test. Values represent means ± SEM.
