Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 4;159(2):362–373. doi: 10.1111/j.1476-5381.2009.00531.x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Journal compilation © 2010 The British Pharmacological Society

PMC Copyright notice

Pre-application of caffeine prevented the resting membrane potential (RMP) hyperpolarization induced by theophylline. In panel A, an experimental recording is shown of the effects of theophylline (3 mM, 5 min) in the presence of caffeine (5 mM, 5 min). Caffeine hyperpolarized the RMP and abolished nitrergic inhibitory junction potentials (IJPs). Further application of theophylline produced RMP depolarization rather than hyperpolarization. (B, panels a–c) IJPs (on an expanded time scale) before and after administration of caffeine and theophylline. (B, panel d) Overlapped IJPs in comparison.