Figure 8.

Effects of N-nitro-L-arginine methyl ester (L-NAME) (A) and L-methionine (B) on long-lasting slow inhibitory junction potential (sIJP) in murine proximal colon circular smooth muscle. (A, panel a) and (B, panel a) depict original tracings, demonstrating that both L-NAME and L-methionine depolarize resting membrane potential. (A, panel b) and (B, panel b) show inhibitory junction potentials (IJPs) (on an expanded time scale) induced by four-pulse nerve stimulation before and after drug administration. L-NAME virtually abolishes the long-lasting sIJP, whereas L-methionine causes only partial inhibition.