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Metabolic rate (kcal/h) of diet-induced obesity mice under thermoneutral conditions after acute dosing with the MCH1 receptor antagonist at 30 mg·kg−1 or the vehicle. (A) Time course changes. (B) Average heat output (kcal/h) over 1–8 h after oral dosing. Data are mean ± standard error (n= 8). *P < 0.05 versus vehicle-treated group. MCH, melanin-concentrating hormone.
