. 2009 Dec 10;159(2):374–383. doi: 10.1111/j.1476-5381.2009.00536.x

Table 1.

In vitro profile of the MCH1 receptor antagonist on human and murine MCH receptors

	Binding assay^a			[Ca²⁺]_i mobilization^b
	K_i (nM)			IC₅₀ (nM)
	hMCH1	mMch1	hMCH2	hMCH1
MCH1 antagonist	2.8 ± 0.4	3.8 ± 0.6	>9700 ± 100	26.5 ± 0.9
MCH	0.03 ± 0.01	0.05 ± 0.01	1.6 ± 0.6

K_i values for MCH1 and MCH2 receptors were determined using [¹²⁵I] MCH and [Phe¹³, [¹²⁵I] Tyr¹⁹]-MCH respectively. The values are means ± standard error (n= 3).

IC₅₀, half maximal inhibitory concentration; MCH, melanin-concentrating hormone.