Figure 3.

Verapamil metabolism in the pregnant non-human primate. At 9 min, plasma radioactivity present as verapamil, D-617/717 (also P-glycoprotein substrates) or polar metabolites was not significantly affected by gestational age (n= 5 per gestational age) or the presence of cyclosporin A (CsA). At mid-gestation, the number of animals studied for ¹¹C-verapamil metabolism were 5, 1 and 4 in the presence of 0, 12 and 24 mg·kg⁻¹·h⁻¹ CsA respectively. The corresponding numbers at late gestation were 5, 3 and 2. Data are expressed as mean ± standard deviation.