Figure 5.

Plasma (A,B) and tissues (C–F) total ¹¹C-radioactivity concentration-time profiles after ¹¹C-verapamil administration in a representative animal at mid- (A,C,E) and late (B,D,F) gestation in the absence and presence of 12 mg·kg⁻¹·h⁻¹ cyclosporin A (CsA). The rectangle highlights the first 0–9 min. CsA did not affect the plasma concentration-time profiles of ¹¹C-radioactivity. In contrast, CsA increased the distribution of radioactivity into the maternal brain (C,D) and the fetal liver (E,F).