Table 1.

Effect of pravastatin on distribution of fat depots at 80 weeks of age

	O-C	O-P12-80	O-P28-80	O-P12-28	L-C
Mesentery (g)	13.3 ± 1.4	14.9 ± 0.8	12.8 ± 1.7	7.9 ± 2.6	9.9 ± 0.9b
Epididymis (g)	15.9 ± 1.0	17.4 ± 0.5	17.2 ± 2.1	8.5 ± 3.1a,b,c	12.9 ± 0.5a,b,c
Retroperitoneum (g)	45.6 ± 2.9	40.6 ± 3.5	52.2 ± 7.2	21.3 ± 6.5a,b,c	14.1 ± 0.9a,b,c
Total (g)	74.9 ± 3.6	72.9 ± 2.8	82.3 ± 10.4	37.6 ± 11.9a,b,c	36.9 ± 1.6a,b,c

Values were mean ± SEM of seven to nine rats: significant difference versus

^aO-C,

^bO-P12-80 and

^cO-P28-80.

The O-C and L-C groups were given standard rat diet the entire experimental period. The O-P12-80 group was maintained on a diet containing 0.05% pravastatin from 12 to 80 weeks of age. The O-P28-80 group was maintained on the same pravastatin diet from 28 to 80 weeks of age. The O-P12-28 group received the same pravastatin diet from 12 to 28 weeks of age, and then switched to standard rat chow until 80 weeks of age.