Table 2.

Effect of pravastatin on the pancreatic weight and contents of protein, DNA and insulin at 80 weeks of age

		O-C	O-P12-80	O-P28-80	O-P12-28	L-C
Pancreatic weight (g)		1.20 ± 0.07	1.55 ± 0.09a	1.76 ± 0.10a	0.94 ± 0.12b,c	1.62 ± 0.06a,d
(g·100 g BW)		0.19 ± 0.01	0.24 ± 0.01a	0.27 ± 0.02a	0.16 ± 0.01b,c	0.26 ± 0.01a,d
Pancreatic protein, DNA and insulin contents
Protein	(mg/pancreas)	54.5 ± 7.1	86.9 ± 10.3a	92.9 ± 7.4a	36.5 ± 5.1b,c	106.1 ± 9.0a,d
	(mg/g pancreas)	46.5 ± 6.9	55.4 ± 4.3	52.8 ± 3.3	38.6 ± 5.5b,c	65.2 ± 4.4a,d
DNA	(mg/pancreas)	1.5 ± 0.2	2.4 ± 0.3a	2.7 ± 0.3a	0.7 ± 0.1a,b,c	3.3 ± 0.4a,d
	(mg/g pancreas)	1.3 ± 0.1	1.6 ± 0.1	1.6 ± 0.2	0.8 ± 0.2b,c	2.0 ± 0.2a,d
Insulin	(mmol/pancreas)	15.8 ± 1.3	32.1 ± 4.1a	46.1 ± 4.6a, b	5.9 ± 1.2a,b,c	46.8 ± 5.3a,d
	(mmol·g−1 pancreas)	13.2 ± 1.0	20.5 ± 1.7a	26.4 ± 2.6a	6.0 ± 0.9a,b,c	28.5 ± 2.5a,d

Values were mean ± SEM of seven to nine rats: significant difference versus

^aO-C,

^bO-P12-80,

^cO-P28-80 and

^dO-P12-28.

For key to groups, see Table 1.