Table 3.

Effect of pravastatin on activities of SOD and MPO, expression levels of TGF-β1 and TNF-α mRNA and ss-DNA index in the pancreas at 80 weeks of age

	O-C	O-P12-80	O-P28-80	O-P12-28	L-C
SOD activity (×103 U/pancreas)	0.50 ± 0.13	1.52 ± 0.29a	1.62 ± 0.25a	0.21 ± 0.04a,b,c	1.80 ± 0.13a,d
MPO activity (fold increase over O-C group)	1.00 ± 0.18	0.48 ± 0.05a	0.33 ± 0.04a	1.71 ± 0.26a,b,c	0.26 ± 0.03a,b,d
Expression levels of mRNA (/GAPDH) (fold increase over O-C group)
TGF-β1	1.00 ± 0.18	0.57 ± 0.05a	0.43 ± 0.14a	1.40 ± 0.20b,c	0.31 ± 0.09a,b,d
TNF-α	1.00 ± 0.19	0.21 ± 0.14a	0.15 ± 0.09a	1.37 ± 0.20b,c	0.01 ± 0.01a,d
ss-DNA index (%)	0.55 ± 0.08	0.12 ± 0.05a	0.05 ± 0.02a	1.19 ± 0.23a,b,c	0.03 ± 0.01a,d

Values were mean ± SEM of seven to nine rats: significant difference versus

^aO-C,

^bO-P12-80,

^cO-P28-80 and

^dO-P12-28.

For key to groups, see Table 1.