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Effects of antidepressants on steady state intracellular pH (pHi) of BCECF-laden hippocampal CA3 neurones. Application periods of drugs at indicated concentrations are shown as shaded areas. (A) Amitriptyline, (B) trimipamine, (C) citalopram, (D) mirtazapine. Curves represent sliding averages from four to eight data points measured in one pyramidal soma. In (B), pHi deflections within near-by regions (150–250 µm2) of the stratum radiatum are additionally shown.
