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. 2009 Dec 7;285(9):6198–6207. doi: 10.1074/jbc.M109.056648

FIGURE 3.

FIGURE 3.

Hepatic BI-1 expression improves insulin sensitivity and glucose metabolism in db/db mice. a, shown are blood glucose concentrations (mg/dl) in db/db mice immediately before and 24 and 120 h after Ad BI-1 or Ad GFP adenovirus treatment. The results are the mean ± S.E. of n = 10 mice per group (**, p ≤ 0.01). b, shown are overnight fasted blood glucose concentrations (mg/dl) in db/db mice 144 h after adenovirus treatment. The results are the mean ± S.E. of n = 10 mice per group (***, p ≤ 0.001). c, insulin tolerance tests were performed db/db mice 120 h after adenovirus injection. Results are given as the mean ± S.E.; n = 10 per group (*, p ≤ 0.05; **, p ≤ 0.01). d, shown is relative expression of G6p and Pepck mRNA in the liver of Ad BI-1 or Ad GFP infected db/db mice (n = 5 per group; *** p ≤ 0.001). e, pyruvate tolerance tests were performed on db/db mice 120 h after adenovirus injection. Results are given as the mean ± S.E., n = 7–8 per group (*, p ≤ 0.05; ***, p ≤ 0.001). f, daily food intake was measured 24, 48, and 72 h after adenovirus injection. Results are given as the mean ± S.E. (n = 7–8 per group). g, body weight was measured 72 h after adenovirus injection. Results are given as the mean ± S.E., n = 7–8 per group. h, relative fat mass was determined by NMR analysis 128 h after adenovirus injection. Results are given as the mean ± S.E., n = 7–8 per group.