FIGURE 6.
Adenovirus-mediated expression of BI-1 in the liver induces steatosis and decreases circulating cholesterol and triglycerides. a, representative livers of Ad BI-1- or Ad GFP-infected HFD-fed mice are shown on the left. Hematoxylin and eosin (H&E) and Oil Red O stainings of liver sections of Ad BI-1- or Ad GFP-infected ND- and HFD-fed mice are shown on the right. b, shown are fasting serum cholesterol concentrations from Ad BI-1- or Ad GFP-infected ND, HFD, and db/db mice (n = 9 per group; ***, p ≤ 0.001). c, shown is fasting serum triglyceride concentrations from Ad BI-1- or Ad GFP-infected ND, HFD, and db/db mice (n = 9 per group; *, p ≤ 0.05; ***, p ≤ 0.001).