FIGURE 7.

Effect of adenovirus-mediated expression of BI-1 on hepatic liver metabolism. a, shown is relative mRNA expression of sterol response element-binding protein 1 (Srebp1), PPARγ coactivator 1α (Pgc1α), peroxisome proliferator-activated receptor α and γ (Pparα, Pparγ), stearoyl-coenzyme A desaturase 1 (Scd1), and fatty acid synthase (Fasn) in the liver of Ad BI-1- or Ad GFP-infected ND and HFD mice as measured by real-time PCR (n = 5 per group). b, shown are C/EBPα, SREBP1, FASN, and PPARγ protein levels in the liver of Ad BI-1- or Ad GFP-infected ND- and HFD-fed mice as assessed by immunoblotting (n = 4–5 of each group). c, shown are C/EBPα, SREBP1, FASN, and PPARγ protein levels in the liver of Ad BI-1- or Ad GFP-infected db/db mice as assessed by immunoblotting (n = 4–5 of each group).