FIGURE 5.

Structural model of Fbl N2N3 subdomains in complex with γ-chain peptide. The fibrinogen-derived peptide is shown as a ball and stick object colored by atom type (carbon, gray; nitrogen, blue; oxygen, red). Residues Asn²⁷⁰, Tyr³²², Trp⁵⁰⁷, and Glu⁵¹⁰ are shown as stick objects in cyan. As in the case of ClfA, the conserved residues Tyr³²² and Trp⁵⁰⁷ could help Fbl anchor the peptide through stacking interaction. Side chain atoms of Lys⁴⁰⁶ and Gln⁴⁰⁷ are not shown in the close-up view of the figure (right panel) for clarity. The backbone atoms of Asn²⁷⁰ and Glu⁵¹⁰ of Fbl interact through hydrogen bonding interactions, which are shown as dotted lines.