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. 2009 Dec 21;285(9):6658–6669. doi: 10.1074/jbc.M109.042424

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — LOX and LOXL2 regulation and expression is VHL-dependent. A, LOX and LOXL2 mRNA expression was analyzed by RNase protection assay in von Hippel Lindau-deficient (−VHL) and reconstituted (+VHL) renal cell carcinoma cell lines (A498, RCC4, and RCC10) after hypoxia or DP treatment (co, control/normoxia; hyp, hypoxia, 1% O₂, 16 h; DP, 100 μm, 16 h). B, LOX and LOXL2 expression was analyzed in samples of radical nephrectomies, from patients with renal clear cell carcinomas with loss of VHL (14) (representative samples of 10 analyzed patients; t, tumor; k, kidney; numbers indicate individual patients).