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. 2009 Dec 18;285(9):6725–6738. doi: 10.1074/jbc.M109.054015

FIGURE 2.

FIGURE 2.

Activation of the ERp57 promoter during mouse embryogenesis. Expression of the ERp57 gene was detected as β-galactosidase activity from the β-galactosidase reporter gene inserted in the ERp57 gene within the ERp57+/− mouse (see Fig. 1). A, activation of the ERp57 promoter in mouse blastocysts. High activation of the ERp57 gene was detected in the inner cell mass (icm) of the blastocysts but not in the blastocoels (b) or trophoblasts (t). B, activation of the ERp57 promoter in lung, liver, and spine but not the heart of E13.5 ERp57+/− mouse embryos. C, high activity of the ERp57 promoter in the lung, liver, gut, and spinal cord in an E15.5 ERp57+/− mouse embryo. D, high activity of the ERp57 promoter in the brain, lungs, and liver in an E18.5 an ERp57+/− mouse embryo. E, β-galactosidase staining of a wild-type E15.5 control embryo.