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. 2009 Dec 18;285(9):6725–6738. doi: 10.1074/jbc.M109.054015

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — A model of the relationship between STAT3, ERp57, and calreticulin. This model shows cross-talk between ERp57, calreticulin, and STAT3 signaling. ERp57 forms functional complexes with calnexin and calreticulin to promote protein folding, disulfide bond formation, and isomerization. ERp57 is also critical for MHC class I biosynthesis and assembly. A model shows that ERp57, from the lumen of the ER, also affects STAT3 signaling and functions as a STAT3 inhibitor. ERp57-dependent modulation of STAT3 is enhanced by complex formation between ERp57 and calreticulin.