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. 2009 Dec 28;285(9):6811–6825. doi: 10.1074/jbc.M109.074690

FIGURE 7.

FIGURE 7.

Direct activation of the Notch pathway increases TRPC6 expression. A and B, time course of Hes1, TRPC6, and TRPC3 transcripts in cultures of PC12 cells that were treated with Jagged1 or a scramble peptide (15 μm). The amount of each transcript was determined in triplicate by real-time RT-PCR and normalized to the expression of housekeeping gene 18S. The values are the means ± S.E. of three independent experiments. *, p < 0.01 (ANOVA with Scheffe post-hoc tests) compared with untreated cultures. C, time course of the SPTB- and LPTB-Numb transcripts in cultures of PC12 cells that were treated with either Jagged1 or scramble peptide (15 μm). Transcript levels were determined in triplicate by real-time PCR. The amount of each transcript was normalized to the expression of housekeeping gene 18S and expressed in -fold change relative the scramble peptide-treated cultures.