Table III.
The power of the LRT and the power for comparison of estimated target dose 1 (discrete method) with placebo for a 5-dose scenario with σ=1.478.
Model | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
N | Design | Const | Emax | LinL | Lin | Exp | Logist | Step 1 | Step 2 | Step 3 |
LRT | ||||||||||
125 | Adaptive | 0.07 | 0.58 | 0.58 | 0.56 | 0.55 | 0.61 | 0.57 | 0.65 | 0.67 |
125 | Equal | 0.05 | 0.44 | 0.46 | 0.45 | 0.41 | 0.54 | 0.42 | 0.58 | 0.60 |
250 | Adaptive | 0.05 | 0.85 | 0.87 | 0.86 | 0.88 | 0.89 | 0.89 | 0.90 | 0.91 |
250 | Equal | 0.05 | 0.71 | 0.73 | 0.71 | 0.71 | 0.82 | 0.69 | 0.86 | 0.87 |
Comparison with placebo | ||||||||||
250 | Adaptive | 0.04 | 0.46 | 0.44 | 0.44 | 0.46 | 0.47 | 0.49 | 0.46 | 0.47 |
250 | Equal | 0.03 | 0.26 | 0.23 | 0.19 | 0.16 | 0.26 | 0.16 | 0.29 | 0.37 |
375 | Adaptive | 0.04 | 0.66 | 0.67 | 0.66 | 0.62 | 0.66 | 0.65 | 0.63 | 0.66 |
375 | Equal | 0.03 | 0.46 | 0.43 | 0.37 | 0.32 | 0.47 | 0.35 | 0.50 | 0.58 |
500 | Adaptive | 0.03 | 0.81 | 0.79 | 0.78 | 0.70 | 0.77 | 0.71 | 0.75 | 0.75 |
500 | Equal | 0.03 | 0.66 | 0.60 | 0.54 | 0.44 | 0.60 | 0.47 | 0.61 | 0.69 |
750 | Adaptive | 0.03 | 0.92 | 0.91 | 0.90 | 0.79 | 0.86 | 0.79 | 0.83 | 0.84 |
750 | Equal | 0.03 | 0.87 | 0.83 | 0.76 | 0.62 | 0.77 | 0.63 | 0.75 | 0.82 |