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. 2010 Feb 1;5:6. doi: 10.1186/1748-717X-5-6

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Copyright ©2010 Jenrow et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Volume densities of activated microglia measured within the SGZ and GCL at 12 weeks post-irradiation. A. Relative to CTL-SHAM, CD68⁺ activated microglia in the SGZ are significantly (p < 0.001) and dose-dependently increased following 10 Gy- and 15 Gy-WBI. B. CD68⁺ activated microglia are unaffected by ramipril in either the Control group (CTL-SHAM vs. CTL-AVS) or in the 10 Gy-WBR group (10 Gy vs. 10 Gy-AVS). Thus, the mitigating effects of ramipril on granule cell progenitor proliferation and neurogenesis following 10 Gy-WBI are not accompanied by a decrease in activated microglia. Error bars represent the standard error of the mean for each treatment group.