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. Author manuscript; available in PMC: 2010 Feb 20.
Published in final edited form as: J Mol Biol. 2008 Jul 7;382(1):24–33. doi: 10.1016/j.jmb.2008.06.085

Figure 2.

Figure 2

Channel activation. a, Currents are shown of Kv1.2 (left) and the paddle chimera channel (right) with CTX-insensitive leak and capacitance currents subtracted. Voltage pulses: holding potential (h.p.) −110 mV, depolarizing steps: −110 mV to +110 mV, ΔV = 10 mV, tail currents measured following a step back to −110 mV. b, The voltage activation curve. Fraction of the maximal current (I/Imax, mean ± s.e.m.) is plotted as a function of the depolarization voltage and fitted with the Boltzmann equation (see methods, n = 9 for Kv1.2 and n = 15 for paddle chimera). Apparent valence Z is 4.6 for Kv1.2 and 3.8 for paddle chimera (calculated at 25 °C)