Table 4.

HPV detection rates in patients with oropharyngeal squamous cell carcinoma

Author	Year	Country	Serum Ab	Pos	Total	%	Comments
Gillison [37]	2000	US		34	60	57	Most HPV 16. HPV more likely in nonsmokers (7/8) than smokers (27/51)
Mellin [38]	2000	Sweden		26	60	43	More women in HPV+ group
Schwartz [39]	2001	US		18	44	41	HPV more common in never smokers 14/42 than ever smokers
Mork [40]	2001	Scandinavia	Yes	9	18	50t
Ringstrom [41]	2002	US		15	29	52	All HPV16
Dahlstrom [42]	2003	US	Yes	41	70	59	HPV16 more common in never smokers (24/35) than ever smokers (17/35) Serum HPV16 L1 Ab predictive for oropharyngeal SCC, OR 59.53 (95% CI: 5.71-620-2)
El-Mofty [43]	2003	US		10	11	91	All tonsil HPV16
Herrero [44]	2003	Multiple	Yes	26	142	18t	Serum HPV16 E6 or E7Ab predictive for oropharyngeal SCC, OR = 9.2 (95% CI: 4.8–17.7)
Begum [45]	2005	US		37	45	82
Hansson [46]	2005	Sweden		21	46	46o	HR HPV DNA in oral mouthwash samples predictive for oropharyngeal SCC, OR = 230 (44–1,200) on multivariate regression analysis
Ibieta [47]	2005	Mexico		4	9	44	Most HPV16, no tonsillar SCC included, only retromolar trigone
Koppikar [48]	2005	India		2	6	33	Most were HPV16, but 14% were multiple HPV infections, (including HPV18, 8, 38)
Kreimer [49]	2005	Multiple	Yes	25	141	18s	Serum HPV VLP Ab plus high tumor viral load predictive for oropharyngeal SCC, OR 12.0 (95% CI 5.2–27.5)
Tachezy [50]	2005	Czech		32	56	57	HPV more common in never smokers (7/7) than ever smokers 28/61
El-Mofty [51]	2006	US		12	20	60	HPV 16
Licitra [52]	2006	Italy		17	90	19	All HPV16, 2 SCC integrated only, remaining both episomal and integrated
Nemes [53]	2006	Hungary		1	8	13	Most HPV16, most integrated HPV more common in never smokers (7/18) than ever smokers 26/61
Weinberger [54]	2006	US		48	79	61
DeSouza [55]	2007	US		72	100	72
Furniss [56]	2007	US	Yes	116	288	40.3s	High HPV16 L1 serum Ab titer predictive for oropharyngeal SCC, OR = 30.3 (95% CI 12.4–73.6)
Pintos [57]	2007	Canada	Yes	9	17	53s	Serum HPV16 VLP predictive for oropharyngeal SCC, OR = 27.68 (95% CI 7.5–102.2) by crude analysis
Smith [58]	2007	US	Yes	35	62	56s	Serum HPV16 E6/E7Ab predictive for oropharyngeal SCC, OR = 72.8 (95% CI 16.0–330)
Schlecht [59]	2007	US		7	17	41	Most HPV16

OR overall risk; Ab serum antibodies; HR high-risk; s seropositivity results; t tumor results; o oral mouthwash results; VLP viral like particles; CI confidence intervals