Fig. 1.

aNUT-rearranged midline carcinoma; monomorphic, poorly differentiated carcinoma with evidence of squamous differentiation. This neoplasm can mimic other undifferentiated neoplasms such as squamous cell carcinoma, Ewing’s sarcoma, and lymphoma. This particular patient initially received an erroneous diagnosis of squamous cell carcinoma. b Partial G-banded karyotype, FISH conducted with a custom-designed BRD4-NUT dual fusion probe set, and schematic illustrating the t(15;19)(q14;p13) identified in a subset of NUT-rearranged midline carcinomas