Table 1. Constants used for simulating Ca2+ waves.
| Symbol | Parameter description | Value |
|---|---|---|
| vmyo | Volume fraction of myoplasm (6, 38) | 0.65 |
| vSR | Volume fraction of SR (6, 38) | 0.035 |
| Cmbuf | Myoplasmic buffer concentration (6, 13) | 175μM |
| Kmbuf | Myoplasmic buffer dissociation constant (6, 13) | 590nM |
| km | Myoplasmic buffer on rate constant* | 100/μM/s |
| CSRbuf | SR buffer concentration (6, 14) | 4.0mM |
| KSRbuf | SR buffer binding constant (6, 14) | 630μM |
| kSRbuf | SR buffer on rate constant* | 100/μM/s |
| VSERCA | Maximum flux on SERCA (14, 38) | 500μM/s |
| δ | Max SR/myoplasm [Ca2+]-gradient (14, 38) | 7000 |
| KSERCA | SERCA Ca2+ dissociation constant (14, 38) | 0.25μM |
| VNCX | Maximum flux on NCX (38) | 1.2mM/s |
| KNCX | NCX Ca2+ dissociation constant (38) | 36μM |
| ksl | Sarcolemmal leak rate constant# | 0.0033/s |
| kleak | Background RyR channel flux constant at filled SR, scaled to fit leak-loak data (49)# | 0.063/s |
| kα+ | Sα on-rate constant | Not limiting |
| kα− | Sα off-rate constant | Not limiting |
| kβ+ | Sβ on-rate constant at loaded SR [Ca2+]=500μM# | 5/μM/s |
| kβ− | Sβ off-rate constant# | 0.59/s |
| kRyR | Activated RyR channel flux constant# | 18/s |
| D1 | Free Ca2+ diffusion coefficient in myoplasm | 500μm2/s |
| D2 | Ca2+-bound myoplasmic buffer diffusion coefficient | 18μm2/s |
| D3 | Unbound myoplasmic buffer diffusion coefficient | 18μm2/s |
| D4 | Free Ca2+ diffusion coefficient in SR | 39μm2/s |
| D5 | Ca2+-bound calsequestrin diffusion coefficient | 0μm2/s |
| D6 | Unbound calsequestrin diffusion coefficient | 0μm2/s |
*
parameter assumed to be diffusion-limited
#
parameter best-fitted to data