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. 2009 Dec 14;588(Pt 3):447–463. doi: 10.1113/jphysiol.2009.184317

Figure 3. Development of fast-AMPAR and slow-NMDAR-EPSCs generated in response to stimulation of the calyx of Held of rat (left, A–F) and mouse (right, G–L).

Figure 3

A and G, NMDAR-EPSC amplitudes decay from P10/11 (rat) and P9 (mouse) until P18. NMDAR peak currents were measured at +45 mV. B and H, slow-EPSC decay time constants accelerate until P18–P21. C and I, the time to peak of the slow EPSC also accelerates until P21 (note that P35 values in mice were so fast that they showed no distinct peak). D and J, fast AMPAR-EPSC amplitudes (measured at −65 mV) increase from P14 to P18; however, the data from rat appear to show a decline again at P21. E and K, fast EPSC decay time constants accelerate. F and L, NMDAR-EPSC to AMPAR-EPSC charge ratios were calculated at positive (+45 mV) and negative voltages (−65 mV), respectively (see Methods). Significance was tested using ANOVA followed by a post hoc test, *Significance relative to youngest age. Data are means ±s.e.m. from 3–9 cells per data point (n= number of cells and is indicated above the data points in A and G). *Statistical significance was accepted if P < 0.05; data are from rat and mouse calyx of Held/MNTB neurons.