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. 2009 Dec 14;588(Pt 3):447–463. doi: 10.1113/jphysiol.2009.184317

Figure 4. NMDAR-EPSCs are maintained at mature calices from P35 mice.

Figure 4

A, superimposed EPSCs from animals aged P12 (grey) or P35 (black) illustrating the large decrease in NMDAR-EPSC amplitude and faster kinetics (+45 mV, top traces, −65 mV, bottom traces). B, the slow EPSC at P35 is blocked by perfusion of the NMDAR antagonist d-AP5 (grey trace, HP =+45 mV). C, summation of NMDAR-EPSCs is an important element of NMDAR activation under physiological conditions; zero current indicated by dashed line, grey areas indicate accumulation of the slow-EPSC/NMDAR currents for P11 (50 Hz), P18 (300 Hz) and P35 (300 Hz) (HP =+45 mV). Data are from mouse calyx of Held/MNTB.