Figure 4.

Sample simulated closed-loop study using a generic glucose measurement model (panel A) and experimentally derived CGM model (panel B). The red continuous curve represents simulated plasma glucose, the green squares represent simulated CGM glucose, the blue piecewise constant curve represents the insulin infusion rate, the green horizontal lines indicate the target glucose range from 3.9 to 8.0 mmol/liter, the magenta and light blue horizontal lines mark mild at 3.5 mmol/liter and significant at 2.8 mmol/liter (panel A) or severe at 2.0 mmol/liter (panel B) hypoglycemia, respectively, the magenta and blue down arrows indicate the meal and prandial insulin bolus, and the red crosses indicate the CGM calibration points.