Table 1.

Model Parameters Estimated from Clinical Data Using Prior Lognormal Distribution.¹⁶

Symbol	Quantity	Meana	Variability
F01	Noninsulin-dependent glucose flux (μmol kg-1 min-1)	11.1	oscillatory
EGP0	Endogenous glucose production extrapolated to zero insulin concentration (μmol kg−1 min−1)	16.9	oscillatory
k12	Transfer rate from nonaccessible to accessible glucose compartment (min−1)	0.060	oscillatory
SID	Insulin sensitivity of glucose disposal (min−1 per mU liter−1)	5.05 × 10−4	oscillatory
SIE	Insulin sensitivity of suppression of endogenous glucose production (per mU liter−1)	0.019	oscillatory
SIT	Insulin sensitivity of glucose transport/distribution (min−1 per mU liter−1)	18.41 × 10−4	oscillatory
kb1	Activation rate of remote insulin effect on glucose distribution (min−1)	0.0034	oscillatory
kb2	Activation rate of remote insulin effect on glucose disposal (min−1)	0.056	oscillatory
kb3	Activation rate of remote insulin effect on endogenous glucose production (min−1)	0.024	oscillatory

^aMean value of the marginal lognormal distribution.