Table 3.
Comparison between Simulated and Real Closed-Loop Experiments Using Clinical Data Collected in the APCam01 study, with Values as Mean ± Standard Deviation or Median (Interquartile Range)
| Measure | Simulations (N = 18) | APCam01 (N = 12) | P value |
|---|---|---|---|
| Starting glucosea (mmol/liter) | 12.2 ± 4.0 | 10.6 ± 3.0 | NSb |
| Overnight glucosea (mmol/liter) | 7.6 ± 1.2 | 7.8 ± 1.4 | NSb |
| Time in targetc (%) | 69 (62–78) | 63 (49–78) | NSd |
| LBGIe (unitless) | 0.5 (0.2–0.9) | 0.3 (0–1.0) | NSd |
| HBGIe (unitless) | 3.4 (1.3–6.8) | 3.7 (0.6–6.8) | NSd |
| Grades A + Bf (%) | 49 (36–58) | 52 (32–66) | NSd |
| Grades E + Ff (%) | 0 (0–2) | 0 (0–1) | NSd |
| Insulin Infusion (U/h) | 1.1 ± 0.4 | 1.3 ± 0.8 | NSb |