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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Clin Cancer Res. 2010 Jan 12;16(2):541–553. doi: 10.1158/1078-0432.CCR-09-1960

Figure 3. The novel viral mutants synergistically enhanced docetaxel-induced cell killing in prostate cancer cell lines.

Figure 3

A) DU145 and PC3 cells were treated with combinations of viral mutants and docetaxel at fixed ratios, EC50-values were calculated for each condition and isobolograms generated to determine synergistic interactions on cell death. The straight line represents the theoretical line for additive effects and each data point the respective combination ratio. B) Caspase 3 activation in response to infection with viral mutants at 100ppc after 24 and 48h in 22Rv1 and DU145 cells. C) Mitochondrial depolarisation (Δψ; TMRE staining) to determine proportion of live 22Rv1 and DU145 cells 24-96h after infection at 10ppc, averages ±SD, n=3.