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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Clin Cancer Res. 2010 Jan 12;16(2):541–553. doi: 10.1158/1078-0432.CCR-09-1960

Table 1.

Combination index (CI) for DU145 and PC3 cells treated with docetaxel and viral mutants at four constant dilution ratios.

Cells Ratio
Ad/Doc
(ppc/nM)		 Combination Index (CI)
Ad5tg AdΔ19K AdΔCR2 AdΔΔ
DU145 0.5 0.98 ad 0.68 S 0.57 S 0.46 S
2.5 1.19 0.63 S 0.50 S 0.91 ad
12.5 1.04 ad 0.75 S 0.48 S 0.88 S
62.5 0.81 S 0.66 S 0.80 S 0.64 S
PC3 0.5 2.48 1.96 2.14 1.63
2.5 3.20 1.7 1.86 1.19
12.5 1.59 1.26 1.29 0.67 S
62.5 1.88 0.78 S 0.76 S 0.49 S

CI values: <0.9=synergy (S), >1.1=antagonism (A), 0.9-1.1=additive effects (ad).