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. 2009 Dec 23;425(Pt 2):295–302. doi: 10.1042/BJ20091352

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© 2010 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

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(a) Myc binds to DNA proximal to transcription initation sites. Myc binds to TFIIH subunits, promotes TFIIH recruitment to chromatin and enhances CTD phosphorylation. Then RNGTT and RNMT bind to phosphorylated CTD and catalyse formation of the 7-methylguanosine cap. (b) SAM is the methyl donor for the cap methylation reaction catalysed by the mRNA cap methyltransferase RNMT. SAH is the byproduct of the reaction, which inhibits RNMT. SAHH hydrolyses SAH to adenosine and homocysteine, thus relieving repression of the RNMT.