Fig. 4.
Determination of the Michaelis constants for substrate 2 and α-chymotrypsin. Substrate 2 was incubated in reaction buffer (100 mM Tris pH 8, 10 mM CaCl2, 50 mM NaCl) with α-chymotrypsin (20 nM) for 5 minutes. The reaction was stopped by diluting the aliquots in a 20 fold excess of 8 M urea. Samples were processed as described in the experimental methods section.