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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Nat Immunol. 2010 Jan 17;11(3):207–215. doi: 10.1038/ni.1839

Figure 5. c-Myc protein abundance directly controls the molecular program of stem cell differentiation, cell cycle entry and self-renewal.

Figure 5

a) Heat map demonstrating relative gene expression signatures of c-Myc-eGFPHi and c-Myc-eGFPLo subsets. A direct comparison to the relative gene expression in Fbw7−/− LSKs is also shown. b) Representative GSEA profiles showing positive correlation of the c-Myc-eGFPLo signature to stem cell gene sets and negative correlation to cell cycle and DNA replication gene sets. c) Representative GSEA profiles showing a positive correlation between both TGF-β and Wnt signaling pathways with c-Myc-eGFPLo gene expression data set.