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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Nat Immunol. 2010 Jan 17;11(3):207–215. doi: 10.1038/ni.1839

Figure 6. Genes over-expressed in c-Myc-EGFPHi cells are directly bound by the c-Myc transcription factor.

Figure 6

a) GSEA analysis showing a positive correlation of c-Myc-eGFPHi gene expression profiles to a direct c-Myc target Chip-on-chip dataset. b) ChIP assay and Heat map of selected genes that are over-expressed in the c-Myc-eGFPHi cells. Red color: gene upregulation, Blue color: gene down-regulation. Two individual chromatin IPs using T-ALL cell line genomic DNA are shown. c) ChIP assay of selected genes using genomic DNA from purified Lineage− c-KiteGFP+ bone marrow progenitor cells. Also, Heat Map showing over expression of selected genes in the c-Myc-eGFPHi LSK subset. Error bars indicate standard deviation (std) from 3 independent experiments.