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. 2009 Nov 10;40(3):141–149. doi: 10.1152/physiolgenomics.00151.2009

Fig. 1.

Fig. 1.

Ingenuity Pathways Analysis (IPA) Network 1 (score = 49) clustered 29 (of 35 in the network) of the resistance loading (RL)-mediated differentially expressed genes in older adults (n = 8) that are directly and indirectly interacting and relevant to stress and cellular compromise (a); inflammation and immune responses (b); necrosis (c); protein synthesis (d); protein degradation (e); skeletal and muscular development (f); cell growth and proliferation (g); myoblast-myotube fusion and cell-cell adhesion (h); fibrosis and connective tissue function (i); and structural integrity (j). Red, upregulated; green, downregulated; white, not differentially expressed but related to this network. *Transcript represented by multiple probe sets. EG, Entrez Gene No. or GeneID. Two heat shock proteins (HSPs) inserted into the network by IPA, HSP27 and HSP70, are synonymous with the differentially expressed HSPB1 and HSPA9, respectively. Such redundant entries occur by default in IPA's automated networking function if a gene within, or synonymous with, a larger “group” enters the network (HSPA9 is synonymous with, or within, the HSP70 group, which contains 11 members; HSPB1 is synonymous with, or within, the HSP27 group, which contains 4 members).