Fig. 4.

Glucose, insulin, and homeostasis model assessment (HOMA)-insulin resistance (IR) measurements confirm that the Chga knockout mouse is insulin sensitive. A: no difference was detected in blood glucose concentration between wild-type (153.5 ± 12.8 mg/dl) and Chga knockout (Chga−/−) mice (145.3 ± 14.6 mg/dl). B: plasma insulin concentration was reduced 4.5-fold in Chga knockout mice (0.44 ± 0.09 ng/ml) compared with wild-type mice (1.96 ± 0.12 ng/ml). C: the HOMA index of IR in Chga knockout mice (1.7 ± 0.3) was 3.8-fold lower than the HOMA index in wild-type mice (6.4 ± 0.7). Data are presented as means ± SE.