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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: ACS Chem Biol. 2010 Jan 15;5(1):35–46. doi: 10.1021/cb9002514

Figure 4. Wnt and FGF2 signaling are regulated by extracellular sulfatase activities.

Figure 4

a) WNT ligands are sequestered by HSPGs. Desulfation of HSPGs by SULF1 liberates the WNTs to interact with Frizzled receptors, activating intracellular signaling pathways. b) FGF2 signaling requires a complex formed from FGF2 ligand, FGFR1, and HSPGs. Desulfation of HSPGs by SULF1 disrupts this complex and thereby reduces FGF2 signaling. SULF2 also affects FGF2 signaling, but direction of the effect and the mechanistic details remain unclear.