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. Author manuscript; available in PMC: 2011 Feb 16.
Published in final edited form as: Circulation. 2010 Feb 1;121(6):792–803. doi: 10.1161/CIRCULATIONAHA.109.900928

Figure 8. Chronic administration of TUDCA reduces ER stress and aortic lesions in mice deficient for both LDLr−/− and AMPKα2.

Figure 8

LDLr−/− and LDLr−/−/AMPKα2−/− mice were fed a high fat diet for 10 weeks, with or without TUDCA treatment. Each group contained six to eight mice. A&B. Chronic administration of TUDCA attenuates ER stress in vivo. ♣p<0.05 vs. LDLr−/−; #p<0.05 vs. LDLr−/−/AMPKα2−/−; C&D. Chronic administration of TUDCA suppresses aortic lesions in LDLr−/−and LDLr/AMPKα2−/− mice. ♣p<0.05 LDLr−/−/AMPKα2−/− vs. LDLr−/−; #p<0.05 LDLr−/− vs. LDLr−/−+TUD; LDLr−/−/AMPKα2−/− vs LDLr−/−/AMPKα2−/−+TUD, respectively; n=6–8. E. Comparison of the effects of TUDCA in LDLr−/− and LDLr−/−/AMPKα2−/− mice, ♣p<0.05 vs. LDLr−/−, n=6–8.