TABLE 3.
Effect of sapA on human inoculation with H. ducreyia
| Volunteer (gender) | No. of days of observation | Strainb | Dose (CFU)c | No. of initial papules | No. of initial pustules | Final outcome of site |
||
|---|---|---|---|---|---|---|---|---|
| No. of papules | No. of pustules | No. of papules/pustules that resolved | ||||||
| 346 (male) | 6 | P | 81 | 3 | 3 | 3 | ||
| M | 42-165 | 3 | 2 | 2 | 1 | |||
| 347 (male) | 6 | P | 81 | 3 | 2 | 2 | 1 | |
| M | 42-165 | 3 | 3 | 3 | ||||
| 348 (male) | 7 | P | 81 | 3 | 1 | 1 | 1 | 1 |
| M | 42-165 | 3 | 0 | 3 | ||||
| 349 (female) | 6 | P | 97 | 3 | 3 | 3 | ||
| M | 47-188 | 3 | 1 | 1 | 2 | |||
| 350 (male) | 6 | P | 97 | 3 | 2 | 2 | 1 | |
| M | 47-188 | 3 | 0 | 3 | ||||
| 351 (female) | 7 | P | 97 | 3 | 1 | 1 | 2 | |
| M | 47-188 | 2 | 0 | 2 | ||||
a
Volunteers 346, 347, and 348 were inoculated in the first iteration; volunteers 349, 350, and 351 were inoculated in the second iteration. See the text for details.
b
P, parent strain 35000HP; M, mutant strain 35000HPsapA.
c
42-165, one dose each of 42, 84, and 165 CFU; 47-188, one dose each of 47, 94, and 188 CFU.