FIG. 5.
Deletion of PILRβ protects mice from S. aureus-mediated pneumonia. C57BL/6J WT and Pilrb−/− mice were infected intranasally with 1 × 108 CFU of S. aureus. Mice were monitored for lung bacterial burden at 6, 24, and 48 h postinfection (n = 8 mice/group in three different experiments) (A); survival (cumulative data from three experiments) (B); serum cytokine levels (mean ± standard error of the mean [SEM] from three experiments each with five to six mice per group (C); and lung mRNA levels for IL-1β, IFN-γ, and IL-12p40 at 48 h postinfection (D). *, P ≤ 0.05; **, P ≤ 0.002; ***, P ≤ 0.001.