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. 2010 Jan 19;78(3):1096–1108. doi: 10.1128/IAI.00943-09

TABLE 2.

Significantly differentially expressed genes associated with the three most significantly differentially expressed canonical pathways, i.e., LPS/IL-1-mediated inhibition of RXR function, LXR/RXR activation, and IL-10 signaling

Pathway and gene Description FDRd FCe
LPS/IL-1-mediated inhibition of RXR functiona
    ApoE Apolipoprotein E 2.42 2.1
    Acsl6 Acyl coenzyme A synthetase long-chain family member 6 0 −5.0
    ApoC2 Apolipoprotein C-II 0.7 2.7
    IL4i1 IL-4-induced 1 2.16 −2.1
    Hmgcs2 3-Hydroxy-3-methylglutaryl coenzyme A synthase 2 (mitochondrial) 1.2 2.9
    IL1r2 IL-1 receptor, type II 0.08 5.8
    Mgst2 Microsomal glutathione S-transferase 2 3.48 2.0
    Gsta4 Glutathione S-transferase A4 0.73 2.7
    Sult1A1 Sulfotransferase family, cytosolic, 1A, phenol preferring, member 1 2.23 2.5
    CD14 CD14 molecule 0.26 3.7
    Xpo1 Exportin 1 (CRM1 homolog, yeast) 2.98 −2.3
    Pltp Phospholipid transfer protein 2.63 2.1
    Abcc3 ATP-binding cassette, subfamily C (CFTR/MRP), member 3 2.81 −2.1
    Aldh6A1 Aldehyde dehydrogenase 6 family, member A1 3.81 2.0
LXR/RXR activationb
    IL1r2 IL-1 receptor, type II 0.08 5.8
    ApoE Apolipoprotein E 2.42 2.1
    IL1rN IL-1 receptor antagonist 3.87 2.0
    CD14 CD14 molecule 0.26 3.7
    ApoC2 Apolipoprotein C-II 0.7 2.7
    Arg2 Arginase, type II 0 6.7
    Pltp Phospholipid transfer protein 2.63 2.1
IL-10 signalingc
    IL1r2 IL-1 receptor, type II 0.08 5.8
    Fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.11 5.2
    IL1rN IL-1 receptor antagonist 3.87 2.0
    CD14 CD14 molecule 0.26 3.7
    Arg2 Arginase, type II 0 6.7
    Fcgr2B Fc fragment of immunoglobulin G, low-affinity IIb, receptor (CD32) 1.79 2.3
a

−Log P value, 5.66E + 00 (Fischer's exact test for significance of pathway [see Materials and Methods]).

b

−Log P value, 3.76E + 00 (Fischer's exact test for significance of pathway [see Materials and Methods]).

c

−Log P value, 3.13E + 00 (Fischer's exact test for significance of pathway [see Materials and Methods]).

d

Only genes with FDRs of <5 are included.

e

FC, fold change in gene expression between strain 927-infected and strain 247-infected mice.