TABLE 2.
Polymyxin B resistance of Y. pestis KIM5 and various deletion mutants
| Straina | Polymyxin B MIC (μg/ml) at:b |
|
|---|---|---|
| 28°C | 37°C | |
| KIM5 | 128 | 1 |
| KIM5 ΔpgmA | 0.031 | 0.5 |
| KIM5 ΔpgmA/pMMB207 | 0.031 | 0.5 |
| KIM5 ΔpgmA/pMMB207-pgmAKIM5 | 64 | 1 |
| KIM5 ΔpgmA/pMMB207-pgmE. coli | 64 | |
| KIM5 ΔpgmA/pMMB208 | 0.031 | |
| KIM5 ΔpgmA/pMMB208-pgmA-HA | 64 | |
| KIM5 ΔpgmA/pMMB208-pgmA-S160A-HA | 0.12 | |
| KIM5 ΔpgmA/pMMB208-pgmA-R521S-HA | 0.063 | |
| KIM5 Δail | 64 | |
| KIM5 ΔyapC | 128 | |
| KIM5 ΔpgmA ΔyapC | 0.031 | |
| KIM5 ΔpgmA Δail | 0.0039 | |
| KIM5 Δail ΔyapC | 64 | |
| KIM5 ΔpgmA ΔyapC Δail | 0.0039 | |
a
The origin of the pgm or pgmA gene is indicated by the subscript.
b
Results are based on three independent experiments that gave identical MICs.