TABLE 1.
Most frequently recognized M. bovis antigens
| M. tuberculosis designationa | M. bovis designationb | Size (amino acids) | Responder frequency (%) | Antigen details |
|---|---|---|---|---|
| Rv3619c | Deleted | 94 | 70 | ESAT-6-like protein 1 (ESXV) |
| Rv1038c | Mb1067c | 98 | 65 | ESAT-6-like protein 2 (ESXJ) |
| Rv1197 | Mb1229 | 98 | 61 | ESAT-6-like protein 3 (ESXK) |
| Rv1792 | Mb1820 | 98 | 61 | ESAT-6-like protein (ESXM) |
| Rv2347c | Deleted | 98 | 61 | ESAT-6-like protein 7 (ESXP) |
| Rv3020c | Mb3046c | 97 | 61 | ESAT-6-like protein (ESXS) |
| Rv2346c | Mb2375c | 94 | 57 | ESAT-6-like protein 6 (ESXO) |
| Rv3017c | Mb3042c | 120 | 57 | ESAT-6-like protein 8 (ESXQ) |
| Rv3444c | Mb3474c | 100 | 57 | ESAT-6-like protein (ESXT) |
| Rv1860 | Mb1891 | 325 | 57 | Immunogenic protein MPT32 |
| Rv3803c | Mb3833c | 299 | 57 | MPT51/MPB51 antigen protein FbpD |
| Rv1037c | Mb1066c | 94 | 48 | ESAT-6-like protein (ESXI) |
| Rv1198 | Mb1230 | 94 | 48 | ESAT-6-like protein (ESXL) |
| Rv2780 | Mb2802 | 371 | 48 | l-Alanine dehydrogenase (TB43) |
| Rv3445c | Mb3475c | 125 | 43 | ESAT-6-like protein (ESXU) |
| Rv0062 | Mb0063 | 380 | 43 | Possible cellulose CELA1 |
| Rv0129c | Mb0134c | 340 | 43 | Antigen 85 complex C |
| Rv3890c | Mb3919c | 95 | 39 | ESAT-6-like protein (ESXC) |
| Rv3905c | Mb3935c | 103 | 39 | ESAT-6-like protein (ESXF) |
| Rv2376c | Mb2397c | 168 | 39 | Low-molecular-wt antigen CFP-2 |
| Rv3666c | Mb3690c | 541 | 39 | Probable dipeptide-binding lipoprotein DppA |
| Rv1886c | Mb1918c | 325 | 39 | Antigen 85 complex B |
| Rv2518c | Mb2547c | 408 | 39 | Probable conserved lipoprotein LppS |
| Rv1174c | Mb1207c | 110 | 39 | Low-molecular-wt T-cell antigen TB8.4 |
a
Rv designation for M. tuberculosis H37Rv protein. Boldface denotes ESAT-6 proteins.
b
Mb designation for M. bovis AF 2122/97 protein. Proteins listed as being deleted are encoded by regions present in M. tuberculosis but not in M. bovis and were included as controls to investigate cross-reactive immune responses.