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. 2010 Jan 19;78(3):1304–1313. doi: 10.1128/IAI.01122-09

FIG. 4.

FIG. 4.

Survival of immunized and nonimmunized mice after Y. pestis KIM5+ challenge. (A) Swiss Webster mice vaccinated s.c. with 3.8 × 107 CFU of χ10010(pCD1Ap) or 2.5 × 107 CFU of Y. pestis KIM5 (Pgm−) were challenged with 1.3 × 107 CFU of Y. pestis KIM5+ via the s.c. route. (B) Swiss Webster mice vaccinated s.c. with 3.0 × 104 CFU of χ10017(pCD1Ap) were challenged with 1.4 × 105 CFU of Y. pestis KIM5+ via the s.c. route. (C) Swiss Webster mice vaccinated s.c. with 3.8 × 107 CFU of χ10010(pCD1Ap), 3.0 × 104 CFU of χ10017(pCD1Ap), or 2.5 × 107 CFU of KIM5 were challenged via the i.n. route with 1.4 × 104 CFU of Y. pestis KIM5+. For panels A and B, survival of immunized mice was significantly greater than that for PBS controls in all experiments (P < 0.001). For panel C, survival of mice immunized with χ10017(pCD1Ap) or KIM5 was significantly greater than that of mice immunized with strain χ10010(pCD1Ap) or PBS controls (P < 0.001). There were 10 mice per vaccination group and 4 mice per control group for each experiment. The experiment was performed twice.