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. 2010 Jan 4;78(3):1333–1338. doi: 10.1128/IAI.00278-09

FIG. 1.

FIG. 1.

Intranasal vaccination with TS CpG induces proliferative immune responses and IFN-γ production. (a) Spleen cells (SC) from mice vaccinated with TS CpG showed significantly greater proliferation in response to recombinant TS protein than those from NC CpG-vaccinated controls (n = 3/group; P < 0.01 by Mann-Whitney U test). (b) SC from TS CpG-vaccinated mice had significantly higher numbers of IFN-γ-producing cells in response to both TS protein (black bars) and an H2-kd-restricted CD8+ T-cell epitope of TS (hatched lines) than those from NC CpG vaccinated controls (n = 3/group; P < 0.01 by Mann-Whitney U test). In both panels, error bars represent the standard errors of the means. These results are representative of five experiments.