TABLE 1.
Absence of fibrinogen results in only a slight, transient decrease in liver bacterial burden on day 17 of infection with M. tuberculosis
| Day | Group | Log10 CFU per organa |
||
|---|---|---|---|---|
| Lung | Spleen | Liver | ||
| 1 | HET | 1.58 ± 0.27 | ||
| 8 | HET | 5.84 ± 0.17 | 5.00 ± 0.14 | 2.53 ± 0.27 |
| KO | 5.70 ± 0.05 | 4.96 ± 0.19 | 2.48 ± 0.33 | |
| 17 | HET | 6.03 ± 0.21 | 4.87 ± 0.35 | 3.89 ± 0.19 |
| KO | 5.93 ± 0.14 | 4.99 ± 0.16 | 3.57 ± 0.05b | |
| 30 | HET | 5.49 ± 0.12 | 4.20 ± 0.17 | 4.28 ± 0.43 |
| KO | 5.41 ± 0.06 | 4.3 ± 0.00 | 4.46 ± 0.73 | |
| 60 | HET | 5.76 ± 0.08 | 4.30 ± 0.35 | 4.68 ± 0.19 |
| KO | 5.71 ± 0.18 | 4.32 ± 0.28 | 4.83 ± 0.02 | |
a
Values are means ± standard deviations (4 mice per group) for M. tuberculosis CFU in organ homogenates from Fib HET or KO mice.
b
Significantly different (P < 0.05) from the value for HET mice at 17 days of infection as calculated by Student's t test.